See manual, up to three, need to be synched between each other using ADAT ports.
Depends on your mainboard and chipset.
With my mainboard I could connect even two UFX+ which have even more ports.
But at a certain point I had to isolate them between dedicated USB3 controller,
because some USB2 devices (ie. Bluetooth USB or USB hubs), seemed to misbehave.
A good board for the UFX+ was the Sonnet Allegro Pro PCIe with 4x USB3 controller.
Unfortunately not available anymore, maybe you find one on eBay.
Needs a PCIe x4 socket on your mainboard.
But maybe it runs already out of the box...
You could also try the Sonnet Allegro (without "Pro") to isolate at least one of the two if there are issues.
The drivers of those cards are very nice, they use MSI, message signalled interrupts, which is a better
scaling interrupt model which has advantages especially under load.
Win7 needs drivers (available) in Win10 these drivers are already included and should be tried 1st.
BR Ramses - UFX III, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1680v4, Win10Pro22H2, Cub13